The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation
Identifieur interne : 000A52 ( Main/Exploration ); précédent : 000A51; suivant : 000A53The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation
Auteurs : Martin Underwood [Royaume-Uni] ; Sandra Eldridge [Royaume-Uni] ; Sallie Lamb [Royaume-Uni] ; Rachel Potter [Royaume-Uni] ; Bartley Sheehan [Royaume-Uni] ; Anne-Marie Slowther [Royaume-Uni] ; Stephanie Taylor [Royaume-Uni] ; Margaret Thorogood [Royaume-Uni] ; Scott Weich [Royaume-Uni]Source :
- Trials ; 2011.
English descriptors
- KwdEn :
- Aged, Cluster Analysis, Depression (diagnosis), Depression (epidemiology), Depression (prevention & control), Depression (psychology), England (epidemiology), Exercise Therapy, Female, Geriatric Assessment, Health Services for the Aged, Homes for the Aged, Humans, Male, Nursing Homes, Prevalence, Psychiatric Status Rating Scales, Research Design, Treatment Outcome.
- MESH :
- geographic , epidemiology : England.
- diagnosis : Depression.
- epidemiology : Depression.
- prevention & control : Depression.
- psychology : Depression.
- Aged, Cluster Analysis, Exercise Therapy, Female, Geriatric Assessment, Health Services for the Aged, Homes for the Aged, Humans, Male, Nursing Homes, Prevalence, Psychiatric Status Rating Scales, Research Design, Treatment Outcome.
Abstract
Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve outcomes among younger and older people. Existing evidence comes from trials that are short, underpowered and not from RNH settings. The aim of the OPERA trial is to establish whether exercise is effective in reducing the prevalence of depression among older RNH residents.
OPERA is a cluster randomised controlled trial. RNHs are randomised to one of two groups with interventions lasting 12 months
Participants are people aged 65 or over who are free of severe cognitive impairment and willing to participate in the study. Our primary outcome is the prevalence of depressive symptoms, a GDS-15 score of five or more, in all participants at the end of the one year intervention period. Our secondary depression outcomes include remission of depressive symptoms and change in GDS-15 scores in those with depressive symptoms prior to randomisation. Other secondary outcomes include, fear of falling, mobility, fractures, pain, cognition, costs and health related quality of life. We aimed to randomise 77 RNHs.
Home recruitment was completed in May 2010; 78 homes have been randomised. Follow up will finish in May 2011 and results will be available late 2011.
[ISRCTN:
Url:
DOI: 10.1186/1745-6215-12-27
PubMed: 21288340
PubMed Central: 3042949
Affiliations:
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Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL</wicri:regionArea><wicri:noRegion>Coventry CV4 7AL</wicri:noRegion></affiliation></author><author><name sortKey="Eldridge, Sandra" sort="Eldridge, Sandra" uniqKey="Eldridge S" first="Sandra" last="Eldridge">Sandra Eldridge</name><affiliation wicri:level="4"><nlm:aff id="I2">Centre for Health Sciences, Queen Mary University of London, , 2 Newark Street, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Health Sciences, Queen Mary University of London, , 2 Newark Street, London E1 2AT</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lamb, Sallie" sort="Lamb, Sallie" uniqKey="Lamb S" first="Sallie" last="Lamb">Sallie Lamb</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL</wicri:regionArea><wicri:noRegion>Coventry CV4 7AL</wicri:noRegion></affiliation></author><author><name sortKey="Potter, Rachel" sort="Potter, Rachel" uniqKey="Potter R" first="Rachel" last="Potter">Rachel Potter</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL</wicri:regionArea><wicri:noRegion>Coventry CV4 7AL</wicri:noRegion></affiliation></author><author><name sortKey="Sheehan, Bartley" sort="Sheehan, Bartley" uniqKey="Sheehan B" first="Bartley" last="Sheehan">Bartley Sheehan</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL</wicri:regionArea><wicri:noRegion>Coventry CV4 7AL</wicri:noRegion></affiliation></author><author><name sortKey="Slowther, Anne Marie" sort="Slowther, Anne Marie" uniqKey="Slowther A" first="Anne-Marie" last="Slowther">Anne-Marie Slowther</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL</wicri:regionArea><wicri:noRegion>Coventry CV4 7AL</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Stephanie" sort="Taylor, Stephanie" uniqKey="Taylor S" first="Stephanie" last="Taylor">Stephanie Taylor</name><affiliation wicri:level="4"><nlm:aff id="I2">Centre for Health Sciences, Queen Mary University of London, , 2 Newark Street, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Health Sciences, Queen Mary University of London, , 2 Newark Street, London E1 2AT</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Thorogood, Margaret" sort="Thorogood, Margaret" uniqKey="Thorogood M" first="Margaret" last="Thorogood">Margaret Thorogood</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL</wicri:regionArea><wicri:noRegion>Coventry CV4 7AL</wicri:noRegion></affiliation></author><author><name sortKey="Weich, Scott" sort="Weich, Scott" uniqKey="Weich S" first="Scott" last="Weich">Scott Weich</name><affiliation wicri:level="1"><nlm:aff id="I1">Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV4 7AL</wicri:regionArea><wicri:noRegion>Coventry CV4 7AL</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trials</title><idno type="e-ISSN">1745-6215</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cluster Analysis</term><term>Depression (diagnosis)</term><term>Depression (epidemiology)</term><term>Depression (prevention & control)</term><term>Depression (psychology)</term><term>England (epidemiology)</term><term>Exercise Therapy</term><term>Female</term><term>Geriatric Assessment</term><term>Health Services for the Aged</term><term>Homes for the Aged</term><term>Humans</term><term>Male</term><term>Nursing Homes</term><term>Prevalence</term><term>Psychiatric Status Rating Scales</term><term>Research Design</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>England</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cluster Analysis</term><term>Exercise Therapy</term><term>Female</term><term>Geriatric Assessment</term><term>Health Services for the Aged</term><term>Homes for the Aged</term><term>Humans</term><term>Male</term><term>Nursing Homes</term><term>Prevalence</term><term>Psychiatric Status Rating Scales</term><term>Research Design</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Abstract</title><sec><title>Background</title><p>Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve outcomes among younger and older people. Existing evidence comes from trials that are short, underpowered and not from RNH settings. The aim of the OPERA trial is to establish whether exercise is effective in reducing the prevalence of depression among older RNH residents.</p></sec><sec><title>Method</title><p>OPERA is a cluster randomised controlled trial. RNHs are randomised to one of two groups with interventions lasting 12 months</p><p><bold>Intervention group</bold>: a depression awareness and physical activity training session for care home staff, plus a whole home physical activation programme including twice weekly physiotherapist-led exercise groups. The intervention lasts for one year from randomisation, or</p><p><bold>Control group</bold>: a depression awareness training session for care home staff.</p><p>Participants are people aged 65 or over who are free of severe cognitive impairment and willing to participate in the study. Our primary outcome is the prevalence of depressive symptoms, a GDS-15 score of five or more, in all participants at the end of the one year intervention period. Our secondary depression outcomes include remission of depressive symptoms and change in GDS-15 scores in those with depressive symptoms prior to randomisation. Other secondary outcomes include, fear of falling, mobility, fractures, pain, cognition, costs and health related quality of life. We aimed to randomise 77 RNHs.</p></sec><sec><title>Discussion</title><p>Home recruitment was completed in May 2010; 78 homes have been randomised. Follow up will finish in May 2011 and results will be available late 2011.</p></sec></sec><sec><title>Trial Registration</title><p>[ISRCTN: <ext-link ext-link-type="uri" xlink:href="http://www.controlled-trials.com/ISRCTN43769277">ISRCTN43769277</ext-link>]</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Llewellyn Jones, Rh" uniqKey="Llewellyn Jones R">RH Llewellyn-Jones</name></author><author><name sortKey="Baikie, Ka" uniqKey="Baikie K">KA Baikie</name></author><author><name sortKey="Smithers, H" uniqKey="Smithers H">H Smithers</name></author><author><name sortKey="Cohen, J" uniqKey="Cohen J">J Cohen</name></author><author><name sortKey="Snowdon, J" uniqKey="Snowdon J">J Snowdon</name></author><author><name sortKey="Tennant, Cc" uniqKey="Tennant C">CC Tennant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mann, Ah" uniqKey="Mann A">AH Mann</name></author><author><name sortKey="Graham, 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uniqKey="Shaw S">S Shaw</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Underwood, Martin" sort="Underwood, Martin" uniqKey="Underwood M" first="Martin" last="Underwood">Martin Underwood</name></noRegion><name sortKey="Eldridge, Sandra" sort="Eldridge, Sandra" uniqKey="Eldridge S" first="Sandra" last="Eldridge">Sandra Eldridge</name><name sortKey="Lamb, Sallie" sort="Lamb, Sallie" uniqKey="Lamb S" first="Sallie" last="Lamb">Sallie Lamb</name><name sortKey="Potter, Rachel" sort="Potter, Rachel" uniqKey="Potter R" first="Rachel" last="Potter">Rachel Potter</name><name sortKey="Sheehan, Bartley" sort="Sheehan, Bartley" uniqKey="Sheehan B" first="Bartley" last="Sheehan">Bartley Sheehan</name><name sortKey="Slowther, Anne Marie" sort="Slowther, Anne Marie" uniqKey="Slowther A" first="Anne-Marie" last="Slowther">Anne-Marie Slowther</name><name sortKey="Taylor, Stephanie" sort="Taylor, Stephanie" uniqKey="Taylor S" first="Stephanie" last="Taylor">Stephanie Taylor</name><name sortKey="Thorogood, Margaret" sort="Thorogood, Margaret" uniqKey="Thorogood M" first="Margaret" last="Thorogood">Margaret Thorogood</name><name sortKey="Weich, Scott" sort="Weich, Scott" uniqKey="Weich S" first="Scott" last="Weich">Scott Weich</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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